Reaction: TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)
- in pathway: Synthesis of wybutosine at G37 of tRNA(Phe)
TYW5 uses 2-oxoglutarate and molecular oxygen to hydroxylate yW-72 (7-(3-amino-3-carboxypropyl)wyosine) at nucleotide 37 of tRNA(Phe), yielding OHyW-72 (7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine), carbon dioxide, and succinate (Noma et al. 2010, Kato et al. 2011).
Reaction - small molecule participants:
CO2 [cytoplasm]
SUCCA [cytoplasm]
2OG [cytoplasm]
O2 [cytoplasm]
Reactome.org reaction link: R-HSA-6783455
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-6783455