Reaction: TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)
- in pathway: tRNA modification in the nucleus and cytosol
The TRMT6:TRMT61A complex transfers a methyl group from S-adenosylmethionine to the 1 position of adenosine-58 of tRNA(Met) (Ozanick et al. 2005). Based on the location of the homologous complex (GCD10:GCD14) in yeast (Anderson et al. 1998), methylation by the TRMT6:TRMT61A complex is inferred to occur in the nucleus.
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-6783492
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6783492