Reaction: KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1
Calmodulin (CALM1) is a ubiquitous key mediator of Ca2+-dependent signalling and is subject to regulatory post-translational modifications which can affect protein-protein interactions. CALM1 is frequently trimethylated at Lys-116 which can influence changes in growth and development and its activator properties with target enzymes. The cytosolic enzyme calmodulin-lysine N-methyltransferase (CAMKMT) catalyses the transfer of 3 methyl groups from high energy donor S-adenosyl-L-methionine (AdoMet) to lysine residue 116 in CALM1, forming a trimethylated protein (triMe-K116-CALM1) (Magnani et al. 2010).
Reaction - small molecule participants:
AdoHcy [cytosol]
AdoMet [cytosol]
AdoHcy [cytosol]
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-6786205
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6786205