Reaction: FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc
- in pathway: GDP-fucose biosynthesis
Fucose-1-phosphate guanylyltransferase (FPGT) functions in a salvage pathway to reutilise L-fucose arising from the turnover of glycoproteins and glycolipids in the liver and other tissues. In the second step of the pathway, FPGT catalyses the transfer a guanylyl group from GTP to fucose-1-phosphate (Fu1P) to form GDP-L-fucose (GDP-Fuc), the high energy donor form used by fucosyltransferases in the Golgi to add fucose moieties to growing glycan chains (Quirk & Seley 2005).
Reaction - small molecule participants:
PPi [cytosol]
GDP-Fuc [cytosol]
GTP [cytosol]
Fuc1P [cytosol]
Reactome.org reaction link: R-HSA-6787533
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Reaction input - small molecules:
GTP(4-)
beta-L-fucose 1-phosphate
Reaction output - small molecules:
diphosphate(3-)
GDP-L-fucose
Reactome.org link: R-HSA-6787533