Reaction: NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447
- in pathway: rRNA modification in the nucleus and cytosol
NOP2 methylates the carbon at the 5th position of the cytosine ring at cytidine-4447 in 28S rRNA (Bourgeois et al. 2015). NOP2 also has a role in rRNA processing that is independent of its methylase activity.
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-6790944
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6790944