Reaction: TP53I3 oxidoreductase generates unstable semiquinones
TP53I3 (PIG3) possesses a NADPH quinone reductase activity, with 1,2-naphthoquinone being its preferred substrate. TP53I3 reduces 1,2-naphthoquinone to a highly unstable semiquinone free radical. Semiquinone reacts with oxygen yielding a quinone and superoxide aninon. Reactive oxygen species (ROS) produced as a result of TP53I3 activity contribute to apoptosis (Porte et al. 2009).
Reaction - small molecule participants:
semiquinone [cytosol]
NADP+ [cytosol]
H+ [cytosol]
1,2-Naphthoquinone [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-6799722
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Reaction input - small molecules:
hydron
1,2-naphthoquinone
NADPH(4-)
Reaction output - small molecules:
semiquinone
NADP(3-)
Reactome.org link: R-HSA-6799722