Reaction: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG
- in pathway: Metabolism of folate and pterines
Cytosolic 5-formyltetrahydrofolate cyclo-ligase (MTHFS) catalyses the irreversible transformation of 5-formyltetrahydrofolate (5-formyl-THF) to 5,10-methenyltetrahydrofolate (5,10-methenyl-THF) (Dayan et al. 1995). MTHFS has higher affinity for the polyglutamate form of 5-formyl-THF (5-formyl-THFPG) (Bertrand et al. 1987). This reaction of tetrahydrofolate metabolism helps regulate carbon flow through the folate-dependent one-carbon metabolic network which is essential for growth and proliferation of cells.
Reaction - small molecule participants:
Pi [cytosol]
H+ [cytosol]
ADP [cytosol]
5,10-methenyl-THFPG [cytosol]
5-formyl-THFPG [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6801342
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Reaction input - small molecules:
5-methyltetrahydrofolyl polyglutamate macromolecule
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
hydron
ADP(3-)
5,10-methenyltetrahydrofolate polyglutamate macromolecule
Reactome.org link: R-HSA-6801342