Reaction: PLK2 phosphorylates NPM1
- in pathway: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
PLK2 phosphorylates NPM1 (nucleophosmin) on serine residue S4, which may be necessary to trigger centrosome duplication (Krause and Hoffmann 2010).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6801675
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6801675