Reaction: PRMT5 methylates TP53
- in pathway: Regulation of TP53 Activity through Methylation
Protein arginine methyltransferase PRMT5, recruited to TP53 (p53) by TTC5 (Strap), monomethylates TP53 on arginine residue R333 and dimethylates TP53 arginine residues R335 and R337. PRMT5-mediated methylation of TP53 modulates the affinity of TP53 for target promoters, promoting expression of cell cycle arrest genes rather than cell death genes (Jansson et al. 2008).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-6804383
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6804383