Reaction: SETD9 methylates TP53
- in pathway: Regulation of TP53 Activity through Methylation
The lysine methyltransferase SETD9 methylates TP53 (p53) on lysine residue K372. Methylation at K372 increases stability of TP53 and promotes transcription of TP53 target genes CDKN1A (p21), BAX and MDM2 (Chuikov et al. 2004, Couture et al. 2006). SETD9 may both mono- and dimethylate TP53 (Bai et al. 2011).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-6805730
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6805730