Reaction: SETD8 methylates TP53
- in pathway: Regulation of TP53 Activity through Methylation
The protein lysine methyltransferase SETD8 (SET8) monomethylates TP53 (p53) on lysine residue K382, resulting in repression of TP53 transcriptional activity (Shi et al. 2007).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-6805740
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6805740