Reaction: EHMT1:EHMT2 dimethylates TP53
- in pathway: Regulation of TP53 Activity through Methylation
The complex of lysine methyltransferases EHMT1 and EHMT2 dimethylates inactive TP53 at lysine residue K373, resulting in additional inhibition of TP53 activity (Huang et al. 2010).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-6805755
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6805755