Reaction: SC5D desaturates LTHSOL to 7-dehydroCHOL
- in pathway: Cholesterol biosynthesis via lathosterol
SC5D (lathosterol oxidase) associated with the endoplasmic reticulum desaturates LTHSOL (lathosterol) to 7-dehydroCHOL (7-dehydrocholesterol) (Brunetti-Pierri et al. 2002; Kandutsch & Russell 1960; Krakowiek et al. 2003; Mitsche et al. 2015).
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
7-dehydroCHOL [endoplasmic reticulum membrane]
H+ [cytosol]
LTHSOL [endoplasmic reticulum membrane]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-6807053
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Reaction input - small molecules:
hydron
5alpha-cholest-7-en-3beta-ol
dioxygen
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
cholesta-5,7-dien-3beta-ol
Reactome.org link: R-HSA-6807053