Reaction: DHCR7 reduces 7-dehydroCHOL to CHOL
- in pathway: Cholesterol biosynthesis via lathosterol
DHCR7 (7-dehydrocholesterol reductase) associated with the endoplasmic reticulum membrane reduces 7-dehydroCHOL (7-dehydrocholesterol) to CHOL (cholesterol) (Kandutsch & Russell1960; Mitsche et al. 2015; Moebius et al. 1998).
Reaction - small molecule participants:
CHOL [endoplasmic reticulum membrane]
NADP+ [cytosol]
H+ [cytosol]
7-dehydroCHOL [endoplasmic reticulum membrane]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-6807055
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Reaction input - small molecules:
hydron
cholesta-5,7-dien-3beta-ol
NADPH(4-)
Reaction output - small molecules:
cholesterol
NADP(3-)
Reactome.org link: R-HSA-6807055