Reaction: NOX4, NOX5 reduce O2 to O2.-
- in pathway: Detoxification of Reactive Oxygen Species
NADPH oxidases 4 and 5 (NOX4, 5) are ER membrane-bound proteins that generates superoxide (O2.-) in endothelial cells (BelAiba et al. 2007). NOX4 functions in association with cytochrome b heterodimer (CYBA:CYBB) on the ER (and nuclear) membrane (Martyn et al. 2006).
Reaction - small molecule participants:
H+ [cytosol]
O2.- [cytosol]
NADP+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-6807557
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Reaction input - small molecules:
dioxygen
NADPH(4-)
Reaction output - small molecules:
hydron
superoxide
NADP(3-)
Reactome.org link: R-HSA-6807557