Reaction: ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG
- in pathway: Metabolism of folate and pterines
ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of cytosolic biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).
Reaction - small molecule participants:
H+ [cytosol]
CO2 [cytosol]
NADPH [cytosol]
THFPG [cytosol]
H2O [cytosol]
10-formyl-THFPG [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-6808496
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Reaction input - small molecules:
water
10-formyltetrahydrofolyl polyglutamate macromolecule
NADP(3-)
Reaction output - small molecules:
hydron
carbon dioxide
NADPH(4-)
tetrahydrofolyl-poly(glutamic acid) macromolecule
Reactome.org link: R-HSA-6808496