Reaction: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus
- in pathway: PI5P Regulates TP53 Acetylation
Translocation of TMEM55B (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) to the nucleus under conditions of cellular stress leads to dephosphorylation of nuclear PI(4,5)P2 to PI5P, thus increasing the concentration of PI5P in the nucleus (Zou et al. 2007). PIP2 and its derivatives are not associated with nuclear envelope structures (Bornenkov et al. 1998) but localize to poorly defined subnuclear compartments called nuclear specks (reviewed by Barlow et al. 2010).
Reaction - small molecule participants:
PI5P [nucleoplasm]
Pi [nucleoplasm]
H2O [nucleoplasm]
PI(4,5)P2 [nucleoplasm]
PI5P [nucleoplasm]
Pi [nucleoplasm]
H2O [nucleoplasm]
PI(4,5)P2 [nucleoplasm]
Reactome.org reaction link: R-HSA-6810410
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
hydrogenphosphate
Reactome.org link: R-HSA-6810410