Reaction: RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
- in pathway: Retrograde transport at the Trans-Golgi-Network
The RIC1:RGP1 complex stimulates nucleotide exchange on trans-Golgi network (TGN)-localized RAB6, activating it (Pusapati et al, 2012; Siniossoglou et al 2001; Siniossoglou et al, 2000). Acitvated RAB6 nucleates a tethering complex at the TGN that is required for fusion of endosome-derived vesicles arriving at the late Golgi (Siniossoglou et al, 2001; Liewen et al, 2005; Perez-Victoria et al, 2008; Perez-Victoria et al, 2009; reviewed in Bonaficino and Hierro, 2011).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-6811429
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-6811429