Reaction: oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
- in pathway: Aspartate and asparagine metabolism
Cytosolic aspartate aminotransferase (glutamate oxaloacetate transaminase 1 - GOT1) catalyzes the reversible reaction of oxaloacetate (OA) and glutamate (L-Glu) to form aspartate (L-Asp) and 2-oxoglutarate (2OG, alpha-ketoglutarate) (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer.
Reaction - small molecule participants:
2OG [cytosol]
L-Asp [cytosol]
L-Glu [cytosol]
OA [cytosol]
Reactome.org reaction link: R-HSA-70581
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Reaction input - small molecules:
L-glutamate(1-)
oxaloacetate(2-)
Reaction output - small molecules:
2-oxoglutarate(2-)
L-aspartate(1-)
Reactome.org link: R-HSA-70581