Reaction: PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate
- in pathway: Gluconeogenesis
Cytosolic GOT1 (glutamate oxaloacetate transaminase 1, also known as aspartate aminotransferase 1) catalyzes the reversible reaction of aspartate (L-Asp) and 2-oxoglutarate (2OG, alpha-ketoglutarate) to form oxaloacetate (OA) and glutamate (L-Glu) (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer).
Reaction - small molecule participants:
L-Glu [cytosol]
OA [cytosol]
2OG [cytosol]
L-Asp [cytosol]
L-Glu [cytosol]
OA [cytosol]
2OG [cytosol]
L-Asp [cytosol]
Reactome.org reaction link: R-HSA-70592
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Reaction input - small molecules:
2-oxoglutarate(2-)
L-aspartate(1-)
2-oxoglutarate(2-)
L-aspartate(1-)
Reaction output - small molecules:
L-glutamate(1-)
oxaloacetate(2-)
L-glutamate(1-)
oxaloacetate(2-)
Reactome.org link: R-HSA-70592