Reaction: GOT2 dimer deaminates L-Asp
- in pathway: Aspartate and asparagine metabolism
Mitochondrial glutamate oxaloacetate transaminase 2 (aspartate aminotransferase 2 - GOT2) catalyzes the reversible reaction of aspartate (L-Asp) and 2-oxoglutarate (2OG, alpha-ketoglutarate) to form oxaloacetate (OA) and glutamate (L-Glu) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.
Reaction - small molecule participants:
OA [mitochondrial matrix]
L-Glu [mitochondrial matrix]
2OG [mitochondrial matrix]
L-Asp [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70596
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Reaction input - small molecules:
2-oxoglutarate(2-)
L-aspartate(1-)
Reaction output - small molecules:
oxaloacetate(2-)
L-glutamate(1-)
Reactome.org link: R-HSA-70596