Reaction: leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
- in pathway: Branched-chain amino acid catabolism
Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate. The active enzyme is a homodimer. Goto et al. (2005) have argued that cytosolic BCAT1 plays a major role in the generation of glutamate involved in synaptic transmission in neural tissue.
Reaction - small molecule participants:
L-Glu [cytosol]
2OG [cytosol]
Reactome.org reaction link: R-HSA-70723
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Reaction input - small molecules:
2-oxoglutarate(2-)
Reaction output - small molecules:
L-glutamate(1-)
Reactome.org link: R-HSA-70723