Reaction: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
- in pathway: Lysine catabolism
The saccharopine dehydrogenase activity of lysine-ketoglutarate reductase / saccharopine dehydrogenase homotetramer in the mitochondrial matrix catalyzes the reaction of lysine, alpha-ketoglutarate, and NADPH + H+ to form saccharopine, NADP+, and H2O (Markovitz et al. 1984; Sacksteder et al. 2001).
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
H2O [mitochondrial matrix]
SACN [mitochondrial matrix]
2OG [mitochondrial matrix]
H+ [mitochondrial matrix]
L-Lys [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70938
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Reaction input - small molecules:
2-oxoglutarate(2-)
hydron
L-lysinium(1+)
NADPH
Reaction output - small molecules:
NADP(+)
water
L-saccharopine
Reactome.org link: R-HSA-70938