Reaction: tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate
- in pathway: Tyrosine catabolism
Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of tyrosine and alpha-keto (2-oxo) glutarate to form 3-(4-hydroxyphenyl)pyruvate and glutamate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.
Reaction - small molecule participants:
L-Glu [cytosol]
HPPYRA [cytosol]
2OG [cytosol]
L-Tyr [cytosol]
Reactome.org reaction link: R-HSA-71155
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Reaction input - small molecules:
2-oxoglutarate(2-)
L-tyrosine zwitterion
Reaction output - small molecules:
L-glutamate(1-)
4-hydroxyphenylpyruvic acid
Reactome.org link: R-HSA-71155