Reaction: kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
- in pathway: Tryptophan catabolism
Cytosolic kynurenine 3-monooxygenase catalyzes the reaction of L-kynurenine, NADPH + H+, and O2 to form 3-hydroxy-L-kynurenine, NADP+, and H2O.
Reaction - small molecule participants:
3HKYN [cytosol]
H2O [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
L-KYN [cytosol]
Reactome.org reaction link: R-HSA-71200
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Reaction input - small molecules:
hydron
dioxygen
NADPH(4-)
L-kynurenine
Reaction output - small molecules:
3-hydroxy-L-kynurenine
water
NADP(3-)
Reactome.org link: R-HSA-71200