Reaction: 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+
- in pathway: Pentose phosphate pathway
Cytosolic phosphogluconate dehydrogenase (PGD) catalyzes the reaction of 6-phospho-D-gluconate and NADP+ to form D-ribulose 5-phosphate, CO2, and NADPH + H+ (Beutler and Kuhl 1985; Rippa et al. 1998). The PGD enzyme is dimeric (Dallocchio et al. 1985).
Reaction - small molecule participants:
H+ [cytosol]
CO2 [cytosol]
NADPH [cytosol]
RU5P [cytosol]
PDG [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-71299
======
Reaction input - small molecules:
6-phosphonatooxy-D-gluconate
NADP(3-)
Reaction output - small molecules:
hydron
carbon dioxide
NADPH(4-)
D-ribulose 5-phosphate(2-)
Reactome.org link: R-HSA-71299