Reaction: GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
- in pathway: Detoxification of Reactive Oxygen Species
Cytosolic glutathione peroxidase (GPX1) tetramer catalyzes the reaction of reduced glutathione and hydrogen peroxide to form reduced glutathione and water (Chu et al. 1993).
Reaction - small molecule participants:
H2O [cytosol]
GSSG [cytosol]
GSH [cytosol]
H2O2 [cytosol]
Reactome.org reaction link: R-HSA-71676
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Reaction input - small molecules:
glutathionate(1-)
hydrogen peroxide
Reaction output - small molecules:
water
glutathione disulfide(2-)
Reactome.org link: R-HSA-71676