Reaction: uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
- in pathway: Pyrimidine catabolism
Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of uracil and NADPH + H+ to form 5,6-dihydrouracil and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).
Reaction - small molecule participants:
NADP+ [cytosol]
5,6-Dihydrouracil [cytosol]
H+ [cytosol]
Ura [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-73585
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Reaction input - small molecules:
hydron
uracil
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
5,6-dihydrouracil
Reactome.org link: R-HSA-73585