Reaction: dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate
- in pathway: Interconversion of nucleotide di- and triphosphates
Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).
Reaction - small molecule participants:
TMP [cytosol]
DHF [cytosol]
THF [cytosol]
dUMP [cytosol]
Reactome.org reaction link: R-HSA-73605
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Reaction input - small molecules:
(6S)-5,6,7,8-tetrahydrofolate(2-)
dUMP(2-)
Reaction output - small molecules:
dTMP(2-)
dihydrofolate(2-)
Reactome.org link: R-HSA-73605