Reaction: thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+
- in pathway: Pyrimidine catabolism
Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of thymine and NADPH + H+ to form 5,6-dihydrothymine and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).
Reaction - small molecule participants:
NADP+ [cytosol]
5,6-Dihydrothymine [cytosol]
H+ [cytosol]
Thy [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-73616
======
Reaction input - small molecules:
hydron
thymine
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
5,6-dihydrothymine
Reactome.org link: R-HSA-73616