Reaction: RDH10,11 oxidise 11cROL to 11cRAL
- in pathway: The canonical retinoid cycle in rods (twilight vision)
Using NADP+ as cofactor, several members of the short-chain dehydrogenases/reductases (SDR) family can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells. Retinol dehydrogenases 10 and 11 (RDH10 and 11) are two such members utilizing the cofactor NADP+ (Wu et al. 2002, Kedishvili et al. 2002 respectively). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.
Reaction - small molecule participants:
H+ [cytosol]
NADPH [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-74872
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Reaction input - small molecules:
NADP(3-)
Reaction output - small molecules:
hydron
NADPH(4-)
Reactome.org link: R-HSA-74872