Reaction: DHRS7B reduces GO3P to HXDG3P
- in pathway: Plasmalogen biosynthesis
DHRS7B (Dehydrogenase/reductase SDR family member 7B) catalyzes the reaction of NADPH and GO3P (O-hexadecyldihydroxyacetone phosphate) to form HXDG3P (1-hexadecyl glycerol-3-phosphate) and NADP+. The enzyme is associated with the outer face of the peroxisomal membrane; its substrates and products are thought to be cytosolic. The properties of the human enzyme are inferred from those of an activity purified from guinea pig liver (Datta et al. 1990). More recent studies of HXDG3P metabolism in cultured human cells in which DHRS7B activity was knocked down confirm the specificity of the human enzyme (Lodhi et al. 2012).
Reaction - small molecule participants:
NADP+ [cytosol]
HXDG3P [cytosol]
H+ [cytosol]
GO3P [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-75883
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Reaction input - small molecules:
hydron
1-alkylglycerone 3-phosphate(2-)
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
1-hexadecyl-sn-glycerol 3-phosphate
Reactome.org link: R-HSA-75883