Reaction: USP9X (FAM) deubiquitinates SMAD4
- in pathway: Downregulation of SMAD2/3:SMAD4 transcriptional activity
USP9X (FAM) deubiquitinates SMAD4, thereby opposing the negative regulatory activity of TRIM33 (Ectodermin) (Dupont et al. 2009).
Reaction - small molecule participants:
H2O [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-870437
======
Reaction input - small molecules:
water
water
Reaction output - small molecules:
Reactome.org link: R-HSA-870437