Reaction: 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde
- in pathway: Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
ADHFE1 catalyzes the reversible reaction of 2-oxoglutarate and 4-hydroxybutyrate to form (R)-2-hydroxyglutarate and succinate semialdehyde (Struys et al. 2005). The localization of human ADHFE1 to the mitochondrial matrix is inferred from the location determined experimentally for its rat homolog (Kaufman et al. 1988).
Reaction - small molecule participants:
SUCCSA [mitochondrial matrix]
2HG [mitochondrial matrix]
2OG [mitochondrial matrix]
HBUT [mitochondrial matrix]
Reactome.org reaction link: R-HSA-880033
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Reaction input - small molecules:
2-oxoglutarate(2-)
4-hydroxybutyrate
Reaction output - small molecules:
4-oxobutanoate
(R)-2-hydroxyglutaric acid
Reactome.org link: R-HSA-880033