Reaction: Activation of RAC1 by the PXN:CRK complex
- in pathway: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
PTK6 (BRK) mediated phosphorylation of PXN (paxillin), which may be triggered by EGF treatment, leads to formation of the RAC1 guanyl nucleotide exchange factor complex composed of PXN and the CRK (CrkII) complex, which includes DOCK180 and ELMO1 or ELMO2. Exchange of RAC1-bound GDP for GTP results in PTK6-induced RAC1 activation, which contributes to cell migration (Chen et al. 2004).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-8848618
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-8848618