Reaction: RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18
- in pathway: COPI-independent Golgi-to-ER retrograde traffic
The RAB3GAP1:RAB3GAP2 complex promotes nucleotide exchange of RAB18 at the ER membrane, activating it (Gerondopoulos et al, 2014). How active RAB18 contributes to COPI-independent retrograde Golgi-to-ER traffic remains to be worked out, however a role in tubule tethering is postulated based on the interaction of RAB18 with components of the ER localized NRZ tethering factor (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Gillingham et al, 2014).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-8850041
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-8850041