Reaction: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
- in pathway: MET activates RAS signaling
GRB2-1 is an adaptor protein for the RAS guanyl nucleotide exchange factor SOS1. GRB2-1, through association with activated receptor tyrosine kinases, such as MET, mediates recruitment of SOS1 to the plasma membrane. At the plasma membrane, SOS1 catalyzes guanyl nucleotide exchange on RAS proteins from GDP to GTP, resulting in RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-8851827
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-8851827