Reaction: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
- in pathway: MET activates RAS signaling
RAS guanyl nucleotide exchange factor SOS1 recruited to MET receptor through association with RANBP9 catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Wang et al. 2002).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-8851877
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-8851877