Reaction: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
- in pathway: MET activates RAS signaling
SOS1, recruited to activated MET receptor via interaction of GRB2 with phosphorylated SHC1-2, catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Pelicci et al. 1995).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-8851899
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-8851899