Reaction: MET bound PI3K generates PIP3
- in pathway: MET activates PI3K/AKT signaling
Phosphatidylinositol-4,5-bisphosphate 3-kinase, PI3K, recruited to activated receptor tyrosine kinases such as EGFR (Rodrigues et al. 2000) and MET (Schaeper et al. 2000) via GAB1, catalyzes phosphatidylinositol-3,4,5-triphosphate (PIP3) synthesis, triggering downstream signaling by AKT family kinases.
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
ADP [cytosol]
ATP [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-8852019
======
Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ADP(3-)
Reactome.org link: R-HSA-8852019