Reaction: Plasma membrane FGFR1 fusions autophosphorylate
- in pathway: Signaling by plasma membrane FGFR1 fusions
Although it hasn't been directly demonstrated in all cases, the ability to promote transformation and anchorage independent growth suggests these fusions undergo autophosphorylation similar to WT FGFR1 proteins. Indeed, active kinase activity has been demonstrated for the the ERLIN2-FGFR1 fusion identified in breast cancer (Singh et al, 2012; Wu et al, 2013; Wang et al, 2014; reviewed in Parker et al, 2014)
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8853325
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8853325