Reaction: HTRA1 hydrolyzes ACAN (Aggrecan)
- in pathway: Degradation of the extracellular matrix
Extracellular HTRA1 (High-temperature requirement A serine peptidase 1) catalyzes the hydrolysis of a specific peptide bond in ACAN (Aggrecan) (Chamberland et al. 2009; Hu et al. 1998). The enzyme is a homotrimer (Truebestein et al. 2011). HTRA1 is thereby implicated in the degradation of extracellular matrix. Indirect studies in mouse model systems (e.g., Oka et al. 2004) that HTRA1 may modulate the activity of Tgf-beta and thereby play additional roles, not annotated here, in the turnover of extracellular matrix both normally and during inflammation.
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-8855825
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-8855825