Reaction: KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark
Once recruited to the SPI1 (PU.1) gene locus, KMT2A (MLL) histone methyltransferase trimethylates nucleosomes associated with the SPI1 promoter and the upstream regulatory element. KMT2A creates the H3K4Me3 mark on histone H3 at the SPI1 gene, a characteristic of transcriptionally active chromatin (Huang et al. 2011).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-8865498
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-8865498