Reaction: PIP5K1C phosphorylates PI(4)P to PI(4,5)P2
- in pathway: Clathrin-mediated endocytosis
Plasma membrane enrichment of PI(4,5)P2 is maintained in part through the action of PI 4 phosphatase 5 kinases (PIPKIs) such as PIP5K1C (Di Paolo and De Camilli, 2006). PIP5K1C interacts directly with AP-2 and the interaction activates the kinase, generating a positive feedback loop for the recruitment of AP-2 to the plasma membrane (Krauss et al, 2006; Bairstow et al, 2006; Thieman et al, 2009; reviewed in Daumke et al, 2014).
Reaction - small molecule participants:
ADP [cytosol]
PI(4,5)P2 [plasma membrane]
ATP [cytosol]
PI4P [plasma membrane]
Reactome.org reaction link: R-HSA-8868066
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reactome.org link: R-HSA-8868066