Meta-Biol

• Pathways

RAB3A is involved in neurotransmitter release at the synaptic vesicle (Fischer et al, 1991; Holz et al, 1994; Geppert et al, 1994; Kapfhamer et al, 2002; reviewed in Pavlos and Jahn, 2011). RAB3A is activated at the synaptic vesicle through the guanine nucleotide exchange activity of RAB3IL1 (also known as GRAB) which promotes the exchange of GDP for GTP (Luo et al, 2001; Yoshimura et al, 2010). RAB3 family members are also activated by the DENN domain-containing GEF MADD, also known as RAB3GEP (Wada et al, 1997; Fukui et al, 1997; Iwasaki et al, 1997; Mahoney et al, 2006). Interaction of RAB3A with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB3A with GDI and CHM proteins.