Reaction: DOCK7 activates RAC1
- in pathway: MET activates RAP1 and RAC1
DOCK7, recruited to the activated MET receptor complex through GAB1 and, possibly, CRK or CRKL, stimulates guanyl nucleotide exchange on RAC1 from GDP to GTP, resulting in RAC1 activation and HGF-stimulated cell migration/invasion (Murray et al. 2014).
Activation of RAC1 in response to HGF stimulation was reported to depend on the endosomal protein RAB5 and RAC1 guanyl exchange factor (GEF) TIAM1 (Palamidessi et al. 2008).
Activation of RAC1 in response to HGF stimulation was reported to depend on the endosomal protein RAB5 and RAC1 guanyl exchange factor (GEF) TIAM1 (Palamidessi et al. 2008).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-8875591
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-8875591