Reaction: HIPK2 phosphorylates RUNX1
Protein serine/threonine kinase HIPK2 phosphorylates RUNX1 upon formation of the RUNX1:CBFB complex. Serine residues S249 and S273 and threonine residue S276 of RUNX1 are phosphorylated by HIPK2. HIPK2-mediated phosphorylation of RUNX1 is implicated as an important regulatory step in hematopoiesis and is disrupted by leukemogenic mutations in CBFB (Aikawa et al. 2006, Wee et al. 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-8878054
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8878054