Reaction: N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A
- in pathway: Protein methylation
Eukaryotic elongation factor 1A (EEF1A) is an essential, highly methylated protein that facilitates translational elongation by delivering aminoacyl-tRNAs to ribosomes. EEF1AKMT1 (N6AMT2) trimethylates EEF1A at Lys-79, a high-stoichiometry N-terminal site that is conserved from yeast to humans (Hamey et al. 2016).
Reaction - small molecule participants:
AdoHcy [cytosol]
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-8931974
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-8931974