Reaction: NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)
- in pathway: tRNA modification in the nucleus and cytosol
NSUN6 methylates position 5 of the cytosine ring of cytidine-72 in the acceptor stem of tRNA(Cys) and tRNA(Thr) (Haag et al. 2015). As the reaction occurs in the cytoplasm and requires the 3' CCA on the tRNA substrates, it is believed to occur late in tRNA biogenesis
Reaction - small molecule participants:
AdoHcy [cytosol]
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-8932765
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-8932765