Reaction: LYPLA2 hydrolyses PALM-C3,4-GAP43
- in pathway: L1CAM interactions
Neuromodulin (GAP43) is a protein associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons (Gauthier-Campbell et al. 2004). An acylation/deacylation cycle is necessary to maintain the steady-state subcellular distribution and biological activity of S-acylated proteins and GAP43 is dually palmitoylated at cysteines 3 and 4 (PALM-C3,4-GAP43). Acyl-protein thioesterase 2 (LYPLA2, APT2) is the protein thioesterase involved in the acylation/deacylation cycle for GAP43 (Tomatis et al. 2010).
Reaction - small molecule participants:
PALM [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-8933328
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Reaction input - small molecules:
water
Reaction output - small molecules:
hexadecanoic acid
Reactome.org link: R-HSA-8933328